Here, we report a novel thermo-triggered-releasing microcapsule for liposoluble drug\ndelivery. Monodisperse microcapsules with a poly(N-isopropylacrylamide-co-methacrylic acid)\nhydrogel shell and an oil core were successfully fabricated by a double coaxial microfluidic device.\nFluorescent dye Lumogen Red F300 as a model liposoluble drug was dissolved in the oil core with\ncontrollable loading capacity. The volume phase transition temperature (VPTT) of the microcapsule\nwas adjusted by copolymerizing with the hydrophilic methacrylic acid. The in vitro release study\ndemonstrates that the shells shrink, leading to the thermo-triggered release of the model drug from the\nmicrocapsules at the environmental temperature above the VPTT, while the swollen hydrogel shells\ncan protect the encapsulated drug from leakage and contamination below the VPTT. The proposed\nmicrocapsule is a promising liposoluble drug delivery system with controllable loading and smart\nthermo-triggered release.
Loading....